Seminario del IIBCE: «Fenotipos Radiómicos, Adiposidad y Riesgo de Cáncer de Mama»

Se realizará el 13 de octubre de 2025 a las 10:30 horas en modalidad híbrida.

El Instituto de Investigaciones Biológicas Clemente Estable (IIBCE) invita al seminario «Radiomic Phenotypes, Adiposity, and Breast Cancer Risk: Linking Imaging Biomarkers to Tissue Biology Across Populations» que se desarrollará en su Sala Sáez del (Avenida Italia 3318) y vía Zoom. Presentará el Dr.John Shepherd, investigador Jefe de la Universidad de Hawaii.

También se puede seguir la conferencia en directo a través del Canal Seminario IIBCE.

Resumen
Radiomic analysis of breast imaging is opening new avenues to understand how tissue composition and microenvironmental biology contribute to cancer risk. Through our NCI-funded Breast SPORE project, we are investigating how AI-derived imaging phenotypes from 2D and 3D mammography relate to breast cancer risk and tissue characteristics among Native Hawaiian, Japanese, Filipina American, and White women. Our first aim evaluates how established radiomic features, including parenchymal texture and density measures, improve risk prediction models by molecular subtype and race/ethnicity in a cohort of nearly half a million screening visits. The second aim examines how these radiomic signatures correlate with tissue protein biomarkers—such as α-SMA, CD36, CD68, and CD8—and gene expression patterns measured by the NanoString Breast 360 panel, illuminating imaging correlates of the tumor microenvironment. Finally, we assess how visceral adiposity, reflected by validated biomarker scores, modifies the relationship between radiomic features and postmenopausal breast cancer risk. Together, these studies link non-invasive imaging phenotypes to tissue biology and population-specific pathways of breast cancer risk and progression.